To pursue its objectives efficiently, IFFIm will outsource its operational work to GAVI (formerly the Global Alliance for Vaccines and Immunization) and its financial management to the World Bank.

GAVI was created in 2000 to respond to, and combat, rapidly declining immunization rates in developing countries. Through public-private partnerships, it accelerates access to vaccines and new vaccine development and ensures future financial sustainability of immunization programs. It has implemented an innovative performance-based grants program that rewards countries for increasing immunization coverage. Since 2000, GAVI has successfully disbursed over US$1.4 billion to over 70 poor countries. Currently, nine sovereign governments, the EU, and the Bill and Melinda Gates Foundation are among the main supporters of GAVI. The World Bank is a member of the GAVI Board. In using IFFIm resources, GAVI will follow its efficient and disciplined approach of reviewing and approving grant requests from eligible recipient countries for specified immunization programs. After receiving certification from GAVI that funds are needed for GAVI-approved immunization programs, IFFIm will transfer available operating funds to GAVI.

The IFFIm Board has appointed the International Bank for Reconstruction and Development (World Bank) as Treasury Manager to IFFIm. The World Bank has been an investor and issuer in the international capital markets for the past 60 years. The World Bank manages its finances according to conservative policies and standards and will ensure that IFFIm conforms to similar standards. With its triple-A credit rating, experience, and knowledge, the World Bank is well suited to provide services to IFFIm ranging from market-based financing strategies and funding operations, intermediation of hedge transactions, multi-donor grant and payment tracking, liquidity and investment management, risk monitoring and asset-liability management, and accounting and reporting.